Our choice of model organisms for systems biotechnology purpose is dictated by the industrial usefulness and scientific interest. We are systematically combining and integrating the results of multi-omics analyses of the genome, transcriptome, proteome, and phenome of the strain to better understand biological systems and the underlying biological networks. We are constructing in silico genome-scale metabolic and regulatory network model of the select organisms, which predictive power will be critical to develop customized genome and cost-effective production of bio-products.


Escherichia coli

A primary goal of the bioprocess development is the cost-effective production of desired products such as therapeutic and industrial proteins on a large scale. E. coli strains are preferred production hosts because of fast growth, facility in genetic modification and cultivation, and high yields for many recombinant proteins.

Escherichia coli K-12 MG1655

• Escherichia coli BL21(DE3)

Escherichia coli B REL606  

• Escherichia coli W ATCC9637


Streptomyces species

Streptomyces are fascinating soil bacteria of major economic and medical importance. As with the other Actinobacteria, Streptomyces are gram-positive, and have large genomes with high GC-content. They produce about 70% of antibiotics of natural origin and other secondary metabolites for treatment of, for example, cancer, a range of infections, high cholesterol, or have immunosuppressive activity. The ability to synthesize high-valued bioactive compounds has driven a great deal of research into using Streptomyces species as an industrial production host. However, complexity of secondary metabolism and its regulation makes it difficult to design and re-engineer Streptomyces as cell factories.

Streptomyces coelicolor A3(2) strain M145

Streptomyces venezuelae ATCC 10712

Streptomyces venezuelae ATCC 15439 (Genome sequencing project was funded by Intelligent Synthetic Biology Center)


Pseudomonas putida

Pseudomonas putida S12

Pseudomonas putida KT2440


Methanotroph (메탄자화균)

• Methylosinus trichosporium OB3b

• Methylocella silvestris BL2


Methylotroph (메탄올자화균)

• Methylobacterium extorquens AM1